Arteriosclerosis Obliterans/ Peripheral artery disease is a condition of the blood vessels that leads to narrowing and hardening of the arteries that supply the legs and feet. This decreases blood flow, which can injure nerves and other tissues.
 

• Pain
• Fatigue
• Burning
• Discomfort in the muscles of your feet, calves, or thighs.
• Numbness of legs or feet may feel numb when you are at rest.
• Legs and feet feel cool to the touch
• Skin may appear pale.

When peripheral artery disease becomes severe, you may have:

• Pain or tingling in the foot or toes, which can be so severe that even the weight of clothes or bed sheets is painful
• Pain that is worse when the leg is elevated and improves when you dangle your legs over the side of the bed

General Measures:

• Balance exercise with rest. Walk or do another activity to the point of pain and alternate it with rest periods. Over time, circulation may improve as new, small (collateral) blood vessels form. Always talk to the doctor before starting an exercise program.
• Stop smoking. Smoking tightens arteries, decreases the blood's ability to carry oxygen, and increases the risk of forming clots (thrombi and emboli).
• Foot care is particularly important if you also have diabetes. Wear shoes that fit properly. Pay attention to any cuts, scrapes, or injuries, and see your doctor right away. The tissues heal slowly and are prone to infection when there is decreased circulation.
• If your cholesterol is high, eat a low-cholesterol and low-fat diet.

Medications may be required to control the disorder, including:

• Aspirin or a medicine called clopidogrel (Plavix), which keeps your blood from forming clots in your arteries. Do NOT stop taking these medications without first talking with your doctor.
• Cilostazol, a medication to enlarge (dilate) the affected artery or arteries for moderate-to-severe cases who are not surgical candidates
• Pain relievers
• Medicine to help lower your cholesterol

If you are taking medicines for high blood pressure or diabetes, take them as your doctor has prescribed.

Surgery may be performed in more severe cases if the condition is affecting your ability to work or pursue essential activities, or you are having pain at rest. Options are:

Peripheral artery bypass surgery of the leg
Angioplasty and stent placement of the peripheral arteries (a similar technique to that used to open the coronary arteries, but performed on the blood vessels of the affected extremity)

Some people with peripheral artery disease may need to have the limb removed (amputated).

Peripheral artery disease is caused by arteriosclerosis, or "hardening of the arteries." This problem occurs when fatty material and a substance called plaque build up on the walls of your arteries. This causes the arteries to become narrower. The walls of the arteries also become stiffer and cannot widen (dilate) to allow greater blood flow when needed.

As a result, when the muscles of your legs are working harder (such as during exercise) they cannot get enough blood and oxygen. Eventually, there may not be enough blood and oxygen, even when the muscles are resting.

This is a common disorder that usually affects men over age 50. People are at higher risk if they have a history of:

• Diabetes
• Abnormal cholesterol
• Heart disease (coronary artery disease)
• High blood pressure (hypertension)
• Kidney disease involving hemodialysis
• Smoking
• Stroke (cerebrovascular disease)

During an examination, the physician may find:

• Weak or absent pulse in the limb
• Loss of hair on the legs or feet
• A whooshing sound with the stethoscope over the artery (arterial bruits)
• Decreased blood pressure in the affected limb

When PAD is more severe, findings may include:

• Paleness of the skin or blue color in the toes or foot (cyanosis)
• Calf muscles that shrink (wither)
• Hair loss over the toes and feet
• Thick toenails
• Shiny, tight skin
• Painful, non-bleeding ulcers on the feet or toes (usually black) that are slow to heal

Blood tests may show high cholesterol or diabetes.
Tests for peripheral artery disease:

• Blood pressure measured in the arms and legs for comparison (ankle/brachial index, or ABI)
• Angiography of the arteries in the legs (arteriography)
• Magnetic resonance angiography or CT angiography
• Doppler ultrasound exam of an extremity

You can usually control peripheral artery disease of the legs with treatment. Surgery provides good symptom relief. Complications may require amputation of the affected leg or foot. You may be at increased risk for coronary artery disease.

• Coronary artery disease
• Blood clots or emboli that block off small arteries
• Impotence
• Open sores (ischemic ulcers) on the lower extremities
• Tissue death (gangrene)

Call your doctor if you have:

• Symptoms of arteriosclerosis of the extremities
• New sores/ulcers
• Signs of infection (fever, redness, general ill feeling)
• A leg or foot that becomes cool to the touch, pale, blue, or numb
• Chest pain or shortness of breath with leg pain
• Leg pain that does not go away, even when you are not walking or moving (called rest pain)
• Legs that are red, hot, or swollen